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TITLE:Development of Novel Chimeric Vaccine and Delivery System for Classical Swine Fever Virus

Authors:Pengcheng Shang, Adriana Avila, Rui Guo, Susan K. Whitaker, Yanhua Li, John Tomich, Raymond R. R. Rowland, Ying Fang

To eliminate the need for a cold chain, DNA vaccine approach was used, in which nanoparticles composed of branched amphiphilic peptide capsules (BAPC) were employed as the DNA delivery agent. The candidate vaccine and the DNA delivery system were evaluated in in vitro expression system and a nursery pig model. This study developed a candidate viral vectored chimeric vaccine and established DNA vaccine delivery system, which could be applied to other emerging and transboundary swine pathogens in the future.